Sweet’s syndrome

Sweet’s syndrome

What is Sweet’s Syndrome?

Sweet’s syndrome (also known as acute febrile neutrophilic dermatosis) is a rare skin disorder characterised by a fever and the appearance of tender red or purple lumps or patches on the skin that may ulcerate. It is not contagious, not hereditary and not a form of skin cancer.

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What does it look like?

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Main body location

Arm, Leg, Neck / Throat

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Can it appear anywhere?

Yes

What causes Sweet’s Syndrome?

In approximately half of those affected it is not possible to identify a cause for Sweet’s syndrome. It is much more common in females between 30-60 years old, although it can occur in males and in other age groups. It can occur in people of any ethnicity and skin type. In the other half of cases, the majority are secondary to an upper respiratory tract or gastrointestinal infection or a drug reaction from medications such as non-steroidal anti-inflammatory medications. In some patients it can be a manifestation of another condition such as inflammatory bowel disease, lupus erythematosus or rheumatoid arthritis. In a few cases, it is a result of hormonal changes such as in pregnancy or thyroid gland disorders and more rarely may be a sign of cancer such as blood, breast or bowel cancer.

What does Sweet’s syndrome of the skin look like?

The most common skin changes in Sweet’s syndrome are raised red, pink or purplish tender skin lumps. These can be small (known as papules, which can be about 5-10 mm) or larger (known as nodules) and can join together to form bigger areas (known as plaques). They can be single or multiple and can appear anywhere on the skin although the arms, face and neck are affected most often. Sometimes blisters or pustules can be seen and the rash may appear at the site of an injury to the skin.

What are the symptoms of Sweet’s syndrome?

Sweet’s syndrome may cause some or all of the following symptoms arising together over a period of hours or a few days:

  • a rash (described above)
  • tiredness, lack of energy and feeling unwell
  • high fever (temperature)
  • aching joints and muscles
  • mouth ulcers
  • sore red eyes

How will Sweet’s syndrome be diagnosed?

Tests that are useful in Sweet’s syndrome include:

  1. Skin biopsy.This is an important test. A sample of the abnormal skin may be taken by your dermatologist. The skin sample is then examined under a microscope in the laboratory. It takes time for the sample to be processed and analysed by a pathologist (specialist doctor) so you will not get the result on the day.
  2. Blood tests such as high levels of a type of white blood cells called neutrophils, can help to make a diagnosis of Sweet’s syndrome.
  3. Your doctor may recommend other blood tests or imaging studies such as X-rays or CT scans to look for an underlying cause of the Sweet’s syndrome, if suspected.
  4. If a medication is thought to be responsible, your doctor may recommend stopping it for a while to see if this improves your symptoms

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This information is provided by the British Association of Dermatologists.


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