Bowen’s disease

Bowen’s disease

What is squamous cell carcinoma in situ?

Squamous cell carcinoma in situ (SCC in situ) is a growth of cancerous cells located in the outer layer of the skin. It is often called ‘Bowen disease’ or ‘Intraepidermal carcinoma (IEC)’. SCC in situ is not a serious condition, but it can, very occasionally, progress to an invasive skin cancer known as squamous cell carcinoma (SCC). For this reason, dermatologists usually treat, or at least monitor, SCC in situ. 

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What does it look like?

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Main body location

All over / widespread

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Can it appear anywhere?

Yes


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What causes squamous cell carcinoma in situ?

Most cases of SCC in situ develop as a result of long-term sun exposure.  People who have a weakened immune system and are on long term immunosuppression medication are more likely to get SCC in situ. Very occasionally, SCC in situ may develop after radiotherapy, longstanding arsenic ingestion (very rare nowadays) or due to the human papillomavirus (a common virus that can cause viral warts). SCC in situ is not infectious and is not caused by an allergy.

Is squamous cell carcinoma in situ hereditary?

No, but some of the factors that increase the risk of getting it, such as a fair skin and a tendency to burn in the sun, do run in families.

What are its symptoms?

Often there are no symptoms, although the rough surface may catch on clothing.  

What does it look like?

A patch of SCC in situ starts as a small red scaly area on the skin, which grows very slowly. It may reach a diameter of a few centimetres across. It commonly occurs on skin that has been exposed to the sun, especially the face, scalp, and neck, as well as the hands and lower legs. There may be more than one area of skin affected. The development of an ulcer, lump or pain within a patch, may indicate the formation of invasive squamous cell cancer.

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How will it be diagnosed?

A patch of squamous cell carcinoma in situ can look rather like other scaly skin conditions, such as psoriasis. For this reason, it is often examined under a dermatoscope (a magnifying tool used to examine the skin). Sometimes a biopsy (a small sample of skin) may be taken to make the diagnosis.

Can it be cured?

Yes. SCC in situ is confined to the surface of the skin and there are a variety of ways in which it can be removed (see below).  

How can it be treated?

Several treatments are available for Bowen disease:  

Self care (What can I do?)

From now on, you should take precautions to prevent additional patches of squamous cell carcinoma in situ developing:

  • Check your skin regularly for new patches
  • The smaller your patch of squamous cell carcinoma in situ is, the better the results of treatment are likely to be. If you think another patch is developing, see your doctor about it promptly.
  • If the patch changes in any way (e.g. bleeds, ulcerates or develops a lump) contact your doctor as soon as possible as this could be the start of an invasive skin cancer.

Top sun safety tips

Sun protection is recommended for all patients. It is advisable to protect the skin from further sun damage (for example, by wearing a hat, long sleeves and a sunscreen with a high sun protection factor).

  • Protect your skin with clothing. Ensure you wear a hat that protects your face, neck and ears, and a pair of UV protective sunglasses.
  • Make use of shade between 11 am and 3 pm when it’s sunny.
  • It is important to avoid sunburn, which is a sign of damage to your skin and increases your risk of developing a skin cancer in the future. However, even a tan is a sign of skin damage and should be avoided.
  • Use a ‘high protection’ sunscreen of at least SPF 30 which also has high UVA protection. Apply sunscreen generously 15 to 30 minutes before going out in the sun and make sure it is reapplied frequently when in the sun.
  • Keep babies and young children out of direct sunlight.
  • The British Association of Dermatologists recommend that you tell your doctor about any changes to a mole or patch of skin. If your GP is concerned about your skin, you should be referred to a Consultant Dermatologist at no cost to yourself through the NHS. You can check your doctor’s qualifications by searching for them on the GMC register – a Consultant Dermatologist will be listed as being on the Specialist Register for Dermatology.
  • No sunscreen can offer 100% protection and should therefore be used to provide additional protection from the sun, not as an alternative to clothing and shade.
  • Routine sun protection is rarely necessary in the UK for people of colour, particularly those with black or dark brown skin tones. However, there are important exceptions to this; for example, sun protection is important if you have a skin condition, such as photosensitivity, vitiligo or lupus, or if you have a high risk of skin cancer, especially if you are taking immunosuppressive treatments (including organ transplant recipients) or if you are genetically pre-disposed to skin cancer. Outside of the UK in places with more extreme climates, you may need to follow our standard sun protection advice.
  • It may be worth taking vitamin D supplement tablets (available from health food stores) as strictly avoiding sunlight can reduce your vitamin D levels.

Vitamin D advice

The evidence relating to the health effects of serum vitamin D levels, exposure to sunlight and vitamin D intake, is inconclusive. People who are avoiding (or need to avoid) sun exposure may be at risk of vitamin D deficiency and should consider having their serum vitamin D levels checked. If the levels are low, they may consider:

  • taking vitamin D supplements of 10-25 micrograms per day
  • increasing intake of food rich in vitamin D such as oily fish, eggs, meat, fortified margarine and cereals.

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This information is provided by the British Association of Dermatologists.

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